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本书聚焦于成年人疾病的胎儿发育起源问题，通过总结国内外研究进展和作者团队近20年研究成果，揭示了疾病（如代谢性疾病、神经精神性疾病、骨与关节疾病、生殖系统疾病等）的宫内发育起源现象，即孕期不良环境诱导的宫内母源性糖皮质激素过暴露可导致胎儿发育迟缓、出生后多器官发育编程及功能稳态改变、成年后多种疾病易感。同时，本书创新性地提出了胎源性疾病的“两种编程”和“两次打击”学说，系统阐述了“宫内母源性糖皮质激素编程胎儿多疾病易感”的创新理论体系。
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